全部产品分类
品牌 |
Leading Biology | 货号 |
APR10356G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TBLR1 antibody.
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分子量 |
55595 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
TBLR1
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亚型 |
Rabbit IgG
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通用名 |
IRA1, TBLR1
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基因ID |
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UniProt ID |
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功能 |
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
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总结 |
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are tho μght to mediate repression, at least in part, by their ability to recruit histone deacetylases (HDAC) to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes and its presence is tho μght to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Altho μgh TBLR1 is tho μght to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
F-Box-Like/WD Repeat-Containing Protein; Transducin β-Like 1X-Related Protein 1
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说明书 |
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数量 |
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