全部产品分类
品牌 |
Leading Biology | 货号 |
APR15231G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CALR antibody.
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分子量 |
48142 Da
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细胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Note=Also found in cell surface (T cells), cytosol and extracellular matrix Associated with the lytic granules in the cytolytic T-lymphocytes
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宿主 |
Rabbit
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种属反应性 |
Human, Rat
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靶点 |
This CALR Antibody is generated from rabbits immunized with a recombinant protein of human CALR.
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亚型 |
Rabbit Ig
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通用名 |
CRTC
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基因ID |
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UniProt ID |
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功能 |
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
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总结 |
Calreticulin is a multifunctional protein that acts as amajor Ca(2+)-binding (storage) protein in the lumen of theendoplasmic reticulum. It is also found in the nucleus, suggestingthat it may have a role in transcription regulation. Calreticulinbinds to the synthetic peptide KLGFFKR, which is almost identicalto an amino acid sequence in the DNA-binding domain of thesuperfamily of nuclear receptors. Calreticulin binds to antibodiesin certain sera of systemic lupus and Sjogren patients whichcontain anti-Ro/SSA antibodies, it is highly conserved amongspecies, and it is located in the endoplasmic and sarcoplasmicreticulum where it may bind calcium. The amino terminus ofcalreticulin interacts with the DNA-binding domain of theglucocorticoid receptor and prevents the receptor from binding toits specific glucocorticoid response element. Calreticulin caninhibit the binding of androgen receptor to its hormone-responsiveDNA element and can inhibit androgen receptor and retinoic acidreceptor transcriptional activities in vivo, as well as retinoicacid-induced neuronal differentiation. Thus, calreticulin can actas an important modulator of the regulation of gene transcriptionby nuclear hormone receptors. Systemic lupus erythematosus isassociated with increased autoantibody titers against calreticulinbut calreticulin is not a Ro/SS-A antigen. Earlier papers referredto calreticulin as an Ro/SS-A antigen but this was later disproven.Increased autoantibody titer against human calreticulin is found ininfants with complete congenital heart block of both the IgG andIgM classes.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, FC, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
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别名 |
Calreticulin, CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP, grp60, CALR, CRTC
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图像 |
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说明书 |
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数量 |
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