全部产品分类
品牌 |
Leading Biology | 货号 |
APG03164G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ASCL1 antibody(N-term).
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分子量 |
25454 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
63-90 aa
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靶点 |
This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.
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亚型 |
Rabbit Ig
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通用名 |
ASH1, BHLHA46, HASH1
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基因ID |
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UniProt ID |
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功能 |
Transcription factor that controls transcriptional expression of its target genes by binding to the E box (5'-CANNTG- 3'). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Essential for the generation of olfactory and autonomic neurons (By similarity).
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总结 |
This gene encodes a member of the basic helix-loop-helix(BHLH) family of transcription factors. The protein activatestranscription by binding to the E box (5'-CANNTG-3'). Dimerizationwith other BHLH proteins is required for efficient DNA binding.This protein plays a role in the neuronal commitment anddifferentiation and in the generation of olfactory and autonomicneurons. Mutations in this gene may contribute to the congenitalcentral hypoventilation syndrome (CCHS) phenotype in rare cases.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1
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图像 |
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说明书 |
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数量 |
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