全部产品分类
品牌 |
Leading Biology | 货号 |
AMM05848G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DTX1 antibody (Center).
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分子量 |
67368 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
382-410 aa
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靶点 |
This DTX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 382-410 amino acids from the Central region of human DTX1.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1.
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总结 |
DTX1 was identified as encoding a positive regulator of the Notch-signaling pathway in Drosophila. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, FC, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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别名 |
E3 ubiquitin-protein ligase DTX1, 632-, Protein deltex-1, Deltex1, hDTX1, DTX1
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图像 |
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说明书 |
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数量 |
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