全部产品分类
品牌 |
Leading Biology | 货号 |
APR09141G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-BAD(S74) antibody.
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分子量 |
18392 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
This BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S74 of human BAD.
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亚型 |
Rabbit Ig
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通用名 |
BBC6, BCL2L8
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基因ID |
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UniProt ID |
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功能 |
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
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总结 |
The protein encoded by this gene is a member of the BCL-2family. BCL-2 family members are known to be regulators ofprogrammed cell death. This protein positively regulates cellapoptosis by forming heterodimers with BCL-xL and BCL-2, andreversing their death repressor activity. Proapoptotic activity ofthis protein is regulated through its phosphorylation. Proteinkinases AKT and MAP kinase, as well as protein phosphatasecalcineurin were found to be involved in the regulation of thisprotein. Alternative splicing of this gene results in twotranscript variants which encode the same isoform. [provided byRefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
DB, E
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稀释方法 |
DB~~1:500
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别名 |
Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, BAD, BBC6, BCL2L8
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图像 |
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说明书 |
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数量 |
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