全部产品分类
品牌 |
Leading Biology | 货号 |
APR10572G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TSC1 antibody (Center T417).
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分子量 |
129767 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
395-424 aa
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靶点 |
This TSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the Central region of human TSC1.
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亚型 |
Rabbit Ig
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通用名 |
KIAA0243, TSC
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基因ID |
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UniProt ID |
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功能 |
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
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总结 |
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Hamartin, Tuberous sclerosis 1 protein, TSC1, KIAA0243, TSC
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图像 |
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说明书 |
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数量 |
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