全部产品分类
品牌 |
Leading Biology | 货号 |
APR17029G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KIRREL antibody(C-term).
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分子量 |
83536 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
505-534 aa
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靶点 |
This KIRREL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 505-534 amino acids from the C-terminal region of human KIRREL.
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亚型 |
Rabbit Ig
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通用名 |
KIRREL1, NEPH1
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基因ID |
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UniProt ID |
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功能 |
Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
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总结 |
NEPH1 is a member of the nephrin-like protein family,which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). Thecytoplasmic domains of these proteins interact with the C terminusof podocin (NPHS2; MIM 604766), and the genes are expressed inkidney podocytes, cells involved in ensuring size- andcharge-selective ultrafiltration (Sellin et al., 2003 [PubMed12424224]).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, KIRREL1, NEPH1
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图像 |
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说明书 |
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数量 |
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