全部产品分类
品牌 |
Leading Biology | 货号 |
AMM05384G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HLA-C antibody (Center).
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分子量 |
40649 Da
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细胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
66-93 aa
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靶点 |
This HLA-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C.
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亚型 |
Rabbit Ig
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通用名 |
HLAC
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基因ID |
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UniProt ID |
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功能 |
Involved in the presentation of foreign antigens to the immune system.
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总结 |
HLA-C belongs to the HLA class I heavy chain paralogues.This class I molecule is a heterodimer consisting of a heavy chainand a light chain (beta-2 microglobulin). The heavy chain isanchored in the membrane. Class I molecules play a central role inthe immune system by presenting peptides derived from endoplasmicreticulum lumen. They are expressed in nearly all cells. The heavychain is approximately 45 kDa and its gene contains 8 exons. Exonone encodes the leader peptide, exons 2 and 3 encode the alpha1 andalpha2 domain, which both bind the peptide, exon 4 encodes thealpha3 domain, exon 5 encodes the transmembrane region, and exons 6and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 andexon 3 are responsible for the peptide binding specificity of eachclass one molecule. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. Over one hundredHLA-C alleles have been described
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7, HLA-C, HLAC
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图像 |
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说明书 |
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数量 |
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