全部产品分类
品牌 |
Leading Biology | 货号 |
APR13076G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RBP3 antibody (Center).
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分子量 |
135363 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells
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宿主 |
Rabbit
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种属反应性 |
Mouse
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免疫原 |
784-811 aa
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靶点 |
This RBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 784-811 amino acids from the Central region of human RBP3.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
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总结 |
Interphotoreceptor retinol-binding protein is a largeglycoprotein known to bind retinoids and found primarily in theinterphotoreceptor matrix of the retina between the retinal pigmentepithelium and the photoreceptor cells. It is thought to transportretinoids between the retinal pigment epithelium and thephotoreceptors, a critical role in the visual process.The humanIRBP gene is approximately 9.5 kbp in length and consists of fourexons separated by three introns. The introns are 1.6-1.9 kbp long.The gene is transcribed by photoreceptor and retinoblastoma cellsinto an approximately 4.3-kilobase mRNA that is translated andprocessed into a glycosylated protein of 135,000 Da. The amino acidsequence of human IRBP can be divided into four contiguous homologydomains with 33-38% identity, suggesting a series of geneduplication events. In the gene, the boundaries of these domainsare not defined by exon-intron junctions, as might have beenexpected. The first three homology domains and part of the fourthare all encoded by the first large exon, which is 3,180 base pairslong. The remainder of the fourth domain is encoded in the lastthree exons, which are 191, 143, and approximately 740 base pairslong, respectively.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:2000
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别名 |
Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, IRBP, Interstitial retinol-binding protein, RBP3
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图像 |
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说明书 |
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数量 |
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