全部产品分类
品牌 |
Leading Biology | 货号 |
APR12701G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PACRG antibody (N-term).
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分子量 |
33342 Da
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
46-74 aa
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靶点 |
This PACRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human PACRG.
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亚型 |
Rabbit Ig
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通用名 |
GLUP
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基因ID |
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UniProt ID |
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功能 |
Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
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总结 |
This gene encodes a protein that is conserved acrossmetazoans. In vertebrates, this gene is linked in a head-to-headarrangement with the adjacent parkin gene, which is associated withautosomal recessive juvenile Parkinson's disease. These genes areco-regulated in various tissues and they share a bi-directionalpromoter. Both genes are associated with susceptibility to leprosy.The parkin co-regulated gene protein forms a large molecularcomplex with chaperones, including heat shock proteins 70 and 90,and chaperonin components. This protein is also a component of Lewybodies in Parkinson's disease patients, and it suppresses unfoldedPael receptor-induced neuronal cell death. Multiple transcriptvariants encoding different isoforms have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Parkin coregulated gene protein, Molecular chaperone/chaperonin-binding protein, PARK2 coregulated gene protein, PACRG, GLUP
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图像 |
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说明书 |
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数量 |
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