全部产品分类
品牌 |
Leading Biology | 货号 |
AMM07083G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PDZD3 antibody (Center).
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分子量 |
61032 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
258-285 aa
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靶点 |
This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.
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亚型 |
Rabbit Ig
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通用名 |
IKEPP, NHERF4, PDZK2
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基因ID |
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UniProt ID |
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功能 |
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
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总结 |
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) producescGMP following the binding of either endogenous ligands orheat-stable enterotoxins secreted by E. coli and other entericbacteria. Activation of GCC initiates a signaling cascade thatleads to phosphorylation of the cystic fibrosis transmembraneconductance regulator (CFTR; MIM 602421), followed by a net effluxof ions and water into the intestinal lumen. IKEPP is a regulatoryprotein that associates with GCC and regulates the amount of cGMPproduced following receptor stimulation (Scott et al., 2002 [PubMed11950846]).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2
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图像 |
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说明书 |
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数量 |
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