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品牌 |
Leading Biology | 货号 |
APR15371G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CDC42EP2 antibody (C-term).
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分子量 |
22484 Da
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细胞定位 |
Antigen Cellular Localization:
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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免疫原 |
133-160 aa
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靶点 |
This CDC42EP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human CDC42EP2.
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亚型 |
Rabbit Ig
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通用名 |
BORG1, CEP2
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基因ID |
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UniProt ID |
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功能 |
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
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总结 |
CDC42, a small Rho GTPase, regulates the formation ofF-actin-containing structures through its interaction with thedownstream effector proteins. The protein encoded by this gene is amember of the Borg family of CDC42 effector proteins. Borg familyproteins contain a CRIB (Cdc42/Rac interactive-binding) domain.They bind to, and negatively regulate the function of, CDC42.Coexpression of this protein with dominant negative mutant CDC42protein in fibroblast was found to induce pseudopodia formation,which suggested a role of this protein in actin filament assemblyand cell shape control.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2
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图像 |
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说明书 |
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数量 |
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