全部产品分类
品牌 |
Leading Biology | 货号 |
APR16638G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HIRA antibody (N-term).
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分子量 |
111835 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
32-61 aa
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靶点 |
This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human HIRA.
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亚型 |
Rabbit Ig
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通用名 |
DGCR1, HIR, TUPLE1
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基因ID |
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UniProt ID |
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功能 |
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
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总结 |
This gene encodes a histone chaperone that preferentiallyplaces the variant histone H3.3 in nucleosomes. Orthologs of thisgene in yeast, flies, and plants are necessary for the formation oftranscriptionally silent heterochomatin. This gene plays animportant role in the formation of the senescence-associatedheterochromatin foci. These foci likely mediate the irreversiblecell cycle changes that occur in senescent cells. It is consideredthe primary candidate gene in some haploinsufficiency syndromessuch as DiGeorge syndrome, and insufficient production of the genemay disrupt normal embryonic development.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1
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图像 |
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说明书 |
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数量 |
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