全部产品分类
品牌 |
Leading Biology | 货号 |
APR15047G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ARHGEF11 antibody (Center).
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分子量 |
167704 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
605-632 aa
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靶点 |
This ARHGEF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 605-632 amino acids from the Central region of human ARHGEF11.
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亚型 |
Rabbit Ig
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通用名 |
KIAA0380
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基因ID |
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UniProt ID |
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功能 |
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
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总结 |
Rho GTPases play a fundamental role in numerous cellularprocesses that are initiated by extracellular stimuli that workthrough G protein coupled receptors. The encoded protein may form acomplex with G proteins and stimulate Rho-dependent signals. Asimilar protein in rat interacts with glutamate transporter EAAT4and modulates its glutamate transport activity. Expression of therat protein induces the reorganization of the actin cytoskeletonand its overexpression induces the formation of membrane rufflingand filopodia. Two alternative transcripts encoding differentisoforms have been described.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF, ARHGEF11, KIAA0380
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图像 |
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说明书 |
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数量 |
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