全部产品分类
品牌 |
Leading Biology | 货号 |
APR07646G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EGLN2 antibody (N-term).
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分子量 |
43650 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
96-123 aa
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靶点 |
This EGLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the N-terminal region of human EGLN2.
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亚型 |
Rabbit Ig
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通用名 |
EIT6
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基因ID |
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UniProt ID |
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功能 |
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferencially recognized via a LXXLAP motif.
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总结 |
The hypoxia inducible factor (HIF) is a transcriptionalcomplex which is involved in oxygen homeostasis. At normal oxygenlevels, the alpha subunit of HIF is targeted for degration byprolyl hydroxylation. This gene encodes an enzyme responsible forthis posttranslational modification. Multiple alternatively splicedvariants, encoding the same protein, have been identified.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Egl nine homolog 2, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF-prolyl hydroxylase 1, HPH-1, Prolyl hydroxylase domain-containing protein 1, PHD1, EGLN2, EIT6
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图像 |
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说明书 |
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数量 |
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