全部产品分类
品牌 |
Leading Biology | 货号 |
APR15066G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ASGR1 antibody (N-term).
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分子量 |
33186 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform H1a: Membrane; Single-pass type II membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
1-30 aa
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靶点 |
This ASGR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ASGR1.
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亚型 |
Rabbit Ig
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通用名 |
CLEC4H1
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基因ID |
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UniProt ID |
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功能 |
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
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总结 |
Partially deglycosylated plasma glycoproteins andimmunoglobulin IgA2 allotypes are efficiently and specificallyremoved from circulation by a receptor-mediated process. Theasialoglycoprotein receptor binds to desialylated(galactosyl-terminal) glycoproteins. It transports theseglycoproteins via a series of membrane vesicles and tubules to anacidic-sorting organelle where the receptor and ligand dissociate.Then the receptor is recycled back to the cell surface and theligand is transported to the lysosomes for degradation.Alternatively spliced transcript variants encoding distinctisoforms have been identified.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Asialoglycoprotein receptor 1, ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1
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图像 |
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说明书 |
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数量 |
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