全部产品分类
品牌 |
Leading Biology | 货号 |
APR11040G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD86 antibody (C-term).
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分子量 |
37682 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
269-298 aa
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靶点 |
This CD86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-298 amino acids from the C-terminal region of human CD86.
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亚型 |
Rabbit Ig
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通用名 |
CD28LG2
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基因ID |
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UniProt ID |
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功能 |
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
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总结 |
This gene encodes a type I membrane protein that is amember of the immunoglobulin superfamily. This protein is expressedby antigen-presenting cells, and it is the ligand for two proteinsat the cell surface of T cells, CD28 antigen and cytotoxicT-lymphocyte-associated protein 4. Binding of this protein withCD28 antigen is a costimulatory signal for activation of theT-cell. Binding of this protein with cytotoxicT-lymphocyte-associated protein 4 negatively regulates T-cellactivation and diminishes the immune response. Alternative splicingresults in two transcript variants encoding different isoforms.Additional transcript variants have been described, but theirfull-length sequences have not been determined. [provided byRefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B72, FUN-1, CD86, CD86, CD28LG2
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图像 |
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说明书 |
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数量 |
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