全部产品分类
品牌 |
Leading Biology | 货号 |
APR10549G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRPM4 antibody (C-term).
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分子量 |
134301 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
1121-1149 aa
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靶点 |
This TRPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1121-1149 amino acids from the C-terminal region of human TRPM4.
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亚型 |
Rabbit Ig
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通用名 |
LTRPC4
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基因ID |
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UniProt ID |
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功能 |
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
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总结 |
The protein encoded by this gene is a calcium-activatednonselective ion channel that mediates transport of monovalentcations across membranes, thereby depolarizing the membrane. Theactivity of the encoded protein increases with increasingintracellular calcium concentration, but this channel does nottransport calcium. Two transcript variants encoding differentisoforms have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4, TRPM4, LTRPC4
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图像 |
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说明书 |
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数量 |
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