全部产品分类
品牌 |
Leading Biology | 货号 |
APR09029G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
|
产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PDZK1 antibody (Center).
|
||
分子量 |
57129 Da
|
||
细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Note=Associated with peripheral membranes Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity).
|
||
宿主 |
Rabbit
|
||
种属反应性 |
Human
|
||
免疫原 |
196-224 aa
|
||
靶点 |
This PDZK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human PDZK1.
|
||
亚型 |
Rabbit Ig
|
||
通用名 |
CAP70, NHERF3, PDZD1
|
||
基因ID |
|||
UniProt ID |
|||
功能 |
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
|
||
总结 |
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
|
||
形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
|
||
储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
应用 |
WB, IHC-P, E
|
||
稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
|
||
别名 |
Na(+)/H(+) exchange regulatory cofactor NHE-RF3, NHERF-3, CFTR-associated protein of 70 kDa, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, NaPi-Cap1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3, PDZK1, CAP70, NHERF3, PDZD1
|
||
图像 |
|
||
说明书 |
|||
数量 |
|
||
| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Leading Biology | APR05963G | EGFR Antibody (Y1092) | 100 μl | Polyclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 2 | Leading Biology | APR03116G | BRCA1 Antibody (aa1847-1863) | 100 μl | Polyclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 3 | Leading Biology | AMM05633G | Bombesin Receptor 2 (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 订购 询价 | ||
| 4 | Leading Biology | APR10986G | AP3B1 Antibody (aa2-14) | 50 μg | Polyclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 5 | Leading Biology | APR11512G | Bestrophin-1 (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 订购 询价 | ||
| 6 | Leading Biology | APG01407G | A3 Adenosine Receptor Antibody | 50 μl | Polyclonal Antibodies |
|
￥6950.00 | 订购 询价 |
微信扫描二维码，随时随地与小诺亲密接触，精彩活动，劲爆优惠，触手可得！
销售-华东区