全部产品分类
品牌 |
Leading Biology | 货号 |
APR07135G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Mouse Pdk3 antibody (C-term).
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分子量 |
47923 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion matrix.
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宿主 |
Rabbit
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种属反应性 |
Mouse
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免疫原 |
387-414 aa
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靶点 |
This Mouse Pdk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-414 amino acids from the C-terminal region of mouse Pdk3.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity).
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总结 |
Pdk3 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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别名 |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, Pyruvate dehydrogenase kinase isoform 3, Pdk3
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图像 |
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说明书 |
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数量 |
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