全部产品分类
品牌 |
Leading Biology | 货号 |
APR12388G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HMGN1 antibody (N-term).
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分子量 |
10659 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
1-30 aa
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靶点 |
This HMGN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HMGN1.
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亚型 |
Rabbit Ig
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通用名 |
HMG14
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基因ID |
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UniProt ID |
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功能 |
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
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总结 |
Chromosomal protein HMG14 and its close analog HMG17 (MIM163910) bind to the inner side of the nucleosomal DNA, potentiallyaltering the interaction between the DNA and the histone octamer.The 2 proteins may be involved in the process that maintainstranscribable genes in a unique chromatin conformation. Theirubiquitous distribution and relative abundance, as well as the highevolutionary conservation of the DNA-binding domain of the HMG14family of proteins, suggest that they may be involved in animportant cellular function.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
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别名 |
Non-histone chromosomal protein HMG-14, High mobility group nucleosome-binding domain-containing protein 1, HMGN1, HMG14
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图像 |
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说明书 |
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数量 |
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