全部产品分类
品牌 |
Leading Biology | 货号 |
APR17208G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LOXL3 antibody (C-term).
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分子量 |
83166 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform 1: Secreted, extracellular space
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
715-744 aa
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靶点 |
This LOXL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 715-744 amino acids from the C-terminal region of human LOXL3.
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亚型 |
Rabbit Ig
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通用名 |
LOXL
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基因ID |
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UniProt ID |
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功能 |
Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV.
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总结 |
This gene encodes a member of the lysyl oxidase genefamily. The prototypic member of the family is essential to thebiogenesis of connective tissue, encoding an extracellularcopper-dependent amine oxidase that catalyses the first step in theformation of crosslinks in collagens and elastin. A highlyconserved amino acid sequence at the C-terminus end appears to besufficient for amine oxidase activity, suggesting that each familymember may retain this function. The N-terminus is poorly conservedand may impart additional roles in developmental regulation,senescence, tumor suppression, cell growth control, and chemotaxisto each member of the family. Alternatively spliced transcriptvariants of this gene have been reported but their full-lengthnature has not been determined.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
WB~~1:2000
IHC-P~~1:10~50
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别名 |
Lysyl oxidase homolog 3, 143-, Lysyl oxidase-like protein 3, LOXL3, LOXL
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图像 |
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说明书 |
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数量 |
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