全部产品分类
品牌 |
Leading Biology | 货号 |
AMM07541G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RASGRP2 antibody (N-term).
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分子量 |
69248 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, ruffle membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity)
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
7-34 aa
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靶点 |
This RASGRP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human RASGRP2.
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亚型 |
Rabbit Ig
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通用名 |
CDC25L, MCG7
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基因ID |
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UniProt ID |
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功能 |
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
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总结 |
The protein encoded by this gene is a brain-enrichednucleotide exchanged factor that contains an N-terminal GEF domain,2 tandem repeats of EF-hand calcium-binding motifs, and aC-terminal diacylglycerol/phorbol ester-binding domain. Thisprotein can activate small GTPases, including RAS and RAP1/RAS3.The nucleotide exchange activity of this protein can be stimulatedby calcium and diacylglycerol. Three alternatively splicedtranscript variants encoding the same protein have been found forthis gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
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别名 |
RAS guanyl-releasing protein 2, Calcium and DAG-regulated guanine nucleotide exchange factor I, CalDAG-GEFI, Cdc25-like protein, hCDC25L, F25B33 kinase-like protein, RASGRP2, CDC25L, MCG7
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图像 |
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说明书 |
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数量 |
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