全部产品分类
品牌 |
Leading Biology | 货号 |
APR11665G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CRFR2 antibody (D35).
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分子量 |
47688 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
10-39 aa
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靶点 |
This CRFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from human CRFR2.
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亚型 |
Rabbit Ig
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通用名 |
CRF2R, CRH2R
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基因ID |
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UniProt ID |
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功能 |
G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
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总结 |
Liaw et al. (1996) [PubMed 8536644] stated that there are2 G protein-coupled corticotropin-releasing hormone (CRH; MIM122560) receptors, CRHR1 (MIM 122561) and CRHR2, which they termedthe CRF2 receptor. CRH is a 41-amino acid peptide synthesized inthe hypothalamus that is the principal neuroregulator of thehypothalamic-pituitary-adrenocortical axis and plays an importantrole in coordinating the endocrine, autonomic, and behavioralresponses to stress and immune challenge.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, FC, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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别名 |
Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2, CRHR2, CRF2R, CRH2R
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图像 |
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说明书 |
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数量 |
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