全部产品分类
品牌 |
Leading Biology | 货号 |
APR15553G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality COPE antibody (C-term).
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分子量 |
34482 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
273-300 aa
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靶点 |
This COPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-300 amino acids from the C-terminal region of human COPE.
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亚型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
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总结 |
The product of this gene is an epsilon subunit of coatomerprotein complex. Coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golginon-clathrin-coated vesicles. It is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. Coatomer complex consists ofat least the alpha, beta, beta', gamma, delta, epsilon and zetasubunits. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
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别名 |
Coatomer subunit epsilon, Epsilon-coat protein, Epsilon-COP, COPE
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图像 |
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说明书 |
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数量 |
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