全部产品分类
品牌 |
Leading Biology | 货号 |
APR10397G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TFAM antibody (C-term).
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分子量 |
29097 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
216-246 aa
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靶点 |
This TFAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-246 amino acids from the C-terminal region of human TFAM.
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亚型 |
Rabbit Ig
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通用名 |
TCF6, TCF6L2
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基因ID |
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UniProt ID |
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功能 |
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
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总结 |
This gene encodes a mitochondrial transcription factorthat is a key activator of mitochondrial transcription as well as aparticipant in mitochondrial genome replication. Studies in micehave demonstrated that this gene product is required to regulatethe mitochondrial genome copy number and is essential for embryonicdevelopment. A mouse model for Kearns-Sayre syndrome was producedwhen expression of this gene was eliminated by targeted disruptionin heart and muscle cells.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, FC, IF, WB, E
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稀释方法 |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
IF~~1:10~50
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别名 |
Transcription factor A, mitochondrial, mtTFA, Mitochondrial transcription factor 1, MtTF1, Transcription factor 6, TCF-6, Transcription factor 6-like 2, TFAM, TCF6, TCF6L2
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图像 |
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说明书 |
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数量 |
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