全部产品分类
品牌 |
Leading Biology | 货号 |
APR08361G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MC1R antibody (Center).
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分子量 |
34706 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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宿主 |
Mouse
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种属反应性 |
Human
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免疫原 |
205-232 aa
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靶点 |
This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R.
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克隆号 |
578CT6.2.3
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亚型 |
IgM
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通用名 |
MSHR
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基因ID |
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UniProt ID |
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功能 |
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
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总结 |
This intronless gene encodes the receptor protein formelanocyte-stimulating hormone (MSH). The encoded protein, a sevenpass transmembrane G protein coupled receptor, controlsmelanogenesis. Two types of melanin exist: red pheomelanin andblack eumelanin. Gene mutations that lead to a loss in function areassociated with increased pheomelanin production, which leads tolighter skin and hair color. Eumelanin is photoprotective butpheomelanin may contribute to UV-induced skin damage by generatingfree radicals upon UV radiation. Binding of MSH to its receptoractivates the receptor and stimulates eumelanin synthesis. Thisreceptor is a major determining factor in sun sensitivity and is agenetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skinand hair color, providing evidence that this gene is an importantcomponent in determining normal human pigment variation. [providedby RefSeq].
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形式 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:100~250
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别名 |
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR
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图像 |
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说明书 |
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数量 |
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