全部产品分类
品牌 |
Leading Biology | 货号 |
APR11816G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DYT1 antibody.
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分子量 |
37809 Da
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细胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
Purified His-tagged DYT1 protein(Fragment) was used to produced this monoclonal antibody.
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克隆号 |
583CT1.1.3
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亚型 |
IgG1
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通用名 |
DQ2, DYT1, TA, TORA
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基因ID |
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UniProt ID |
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功能 |
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non- neural tissues.
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总结 |
The protein encoded by this gene is a member of the AAAfamily of adenosine triphosphatases (ATPases), is related to theClp protease/heat shock family and is expressed prominently in thesubstantia nigra pars compacta. Mutations in this gene result inthe autosomal dominant disorder, torsion dystonia 1. [provided byRefSeq].
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形式 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:500~8000
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别名 |
Torsin-1A, Dystonia 1 protein, Torsin ATPase-1A, 364-, Torsin family 1 member A, TOR1A, DQ2, DYT1, TA, TORA
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图像 |
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说明书 |
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数量 |
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