全部产品分类
品牌 |
Leading Biology | 货号 |
AMM07410G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PTPRH antibody (interal region).
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分子量 |
122352 Da
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细胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein. Cytoplasm
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宿主 |
Goat
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亚型 |
IgG
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通用名 |
SAP1
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UniProt ID |
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功能 |
May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion- associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.
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形式 |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
E
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别名 |
Receptor-type tyrosine-protein phosphatase H, R-PTP-H, 3.1.3.48, Stomach cancer-associated protein tyrosine phosphatase 1, SAP-1, Transmembrane-type protein-tyrosine phosphatase type H, PTPRH, SAP1
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说明书 |
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数量 |
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