全部产品分类
品牌 |
Leading Biology | 货号 |
AMM05838G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DORFIN / RNF19 antibody (C-Term).
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分子量 |
90696 Da
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细胞定位 |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients
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宿主 |
Goat
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亚型 |
IgG
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通用名 |
RNF19
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基因ID |
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UniProt ID |
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功能 |
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
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总结 |
Both variants (NP_056250.3; NP_904355.1) encode the same protein.
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形式 |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
E
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别名 |
E3 ubiquitin-protein ligase RNF19A, 6.3.2.-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
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说明书 |
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数量 |
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