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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > CBS Antibody (N-term)

CBS Antibody (N-term)

货号 货期 规格 / 价格 询价
APR10818G 100 μl / ¥5450

CBS Antibody (N-term)

品牌

Leading Biology

货号

APR10818G

产品分类

Polyclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CBS antibody (N-term).

分子量

60587 Da

细胞定位

Antigen Cellular Localization: Cytoplasm. Nucleus

宿主

Rabbit

种属反应性

Human, Mouse

免疫原

104-133 aa

靶点

This CBS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human CBS.

亚型

Rabbit Ig

基因ID

UniProt ID

功能

Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).

总结

CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. This protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.

形式

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC-P, FC, IF, E

稀释方法

WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 IF~~1:10~50

别名

Cystathionine beta-synthase, Beta-thionase, Serine sulfhydrase, CBS

图像

Western blot analysis of CBS Antibody (N-term) (Cat. APR10818G) in mouse kidney tissue and Ramos cell line lysates (35ug/lane). CBS (arrow) was detected using the purified Pab.

CBS Antibody (N-term) (Cat. APR10818G) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CBS Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

CBS Antibody (N-term) (Cat. APR10818G) flow cytometric analysis of Ramos cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

说明书

数量

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