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Bmp3 Antibody (N-term)

AMM08601G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
AMM08601G		100 μl / ￥5450

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Bmp3 Antibody (N-term)

品牌	Leading Biology	货号	AMM08601G
产品分类	Polyclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bmp3 antibody (N-term).
分子量	53372 Da
细胞定位	Antigen Cellular Localization: Secreted.
宿主	Rabbit
种属反应性	Human
免疫原	8-36 aa
靶点	This Bmp3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human Bmp3.
亚型	Rabbit Ig
通用名	BMP3A
基因ID	651
UniProt ID	P12645
功能	Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
总结	The BMPs belong to the TGF-Beta superfamilyBMPs stimulate the production of bone matrix proteins and thereby alter stromal cell and osteoclast proliferation, a key step in bone marrow development. In addition to promoting ectopic bone and cartilage development, BMPs regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. BMPs also play a role in dorsal/ventral patterning. BMP3, highly expressed in lung, ovary and small intestine, participates in cartilage and bone formation. BMP3 and BMP2 genes map to conserved regions between human and mouse.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC-P, E
稀释方法	WB~~1:1000 IHC-P~~1:50~100
别名	Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3, BMP3A
图像	Western blot analysis of hBmp3-E23 (Cat. AMM08601G) in 293 cell line lysates (35ug/lane). BMP3 (arrow) was detected using the purified Pab. Western blot analysis of Bmp3 (arrow) using rabbit polyclonal Bmp3 Antibody (N-term) (Cat. AMM08601G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Bmp3 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
说明书	Product Datasheet Protocol
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