全部产品分类
品牌 |
Leading Biology | 货号 |
APR14248G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RHO antibody (C-term).
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分子量 |
38893 Da
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细胞定位 |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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免疫原 |
310-339 aa
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靶点 |
This RHO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human RHO.
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亚型 |
Rabbit Ig
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通用名 |
OPN2
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基因ID |
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UniProt ID |
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功能 |
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
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总结 |
Retinitis pigmentosa is an inherited progressive diseasewhich is a major cause of blindness in western communities. It canbe inherited as an autosomal dominant, autosomal recessive, orX-linked recessive disorder. In the autosomal dominant form,whichcomprises about 25% of total cases, approximately 30% of familieshave mutations in the gene encoding the rod photoreceptor-specificprotein rhodopsin. This is the transmembrane protein which, whenphotoexcited, initiates the visual transduction cascade. Defects inthis gene are also one of the causes of congenital stationary nightblindness.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Rhodopsin, Opsin-2, RHO, OPN2
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图像 |
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说明书 |
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数量 |
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