全部产品分类
品牌 |
Leading Biology | 货号 |
AMM08665G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PPM1A antibody.
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分子量 |
42448 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization.
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
355-382 aa
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靶点 |
This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-382 amino acids from human PPM1A.
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亚型 |
Rabbit Ig
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通用名 |
PPPM1A
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基因ID |
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UniProt ID |
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功能 |
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
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总结 |
The protein encoded by this gene is a member of the PP2Cfamily of Ser/Thr protein phosphatases. PP2C family members areknown to be negative regulators of cell stress response pathways.This phosphatase dephosphorylates, and negatively regulates theactivities of, MAP kinases and MAP kinase kinases. It has beenshown to inhibit the activation of p38 and JNK kinase cascadesinduced by environmental stresses. This phosphatase can alsodephosphorylate cyclin-dependent kinases, and thus may be involvedin cell cycle control. Overexpression of this phosphatase isreported to activate the expression of the tumor suppressor geneTP53/p53, which leads to G2/M cell cycle arrest and apoptosis.Three alternatively spliced transcript variants encoding distinctisoforms have been described.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, PP2C-alpha, Protein phosphatase IA, PPM1A, PPPM1A
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图像 |
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说明书 |
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数量 |
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