全部产品分类
品牌 |
Leading Biology | 货号 |
APR10872G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ERRFI1 antibody (Center).
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分子量 |
50560 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes (By similarity).
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宿主 |
Rabbit
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种属反应性 |
Human
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免疫原 |
257-286 aa
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靶点 |
This ERRFI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the Central region of human ERRFI1.
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亚型 |
Rabbit Ig
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通用名 |
MIG6
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基因ID |
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UniProt ID |
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功能 |
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
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总结 |
ERRFI1 is a cytoplasmic protein whose expression isupregulated with cell growth (Wick et al., 1995 [PubMed 7641805]).It shares significant homology with the protein product of ratgene-33, which is induced during cell stress and mediates cellsignaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino etal., 2000 [PubMed 11003669]).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
ERBB receptor feedback inhibitor 1, Mitogen-inducible gene 6 protein, MIG-6, ERRFI1, MIG6
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图像 |
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说明书 |
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数量 |
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