全部产品分类
品牌 |
Leading Biology | 货号 |
APR10918G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RB1CC1 antibody (Center).
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分子量 |
183091 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
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宿主 |
Rabbit
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种属反应性 |
Mouse
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免疫原 |
489-515 aa
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靶点 |
This RB1CC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-515 amino acids from the Central region of human RB1CC1.
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亚型 |
Rabbit Ig
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通用名 |
KIAA0203, RBICC
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基因ID |
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UniProt ID |
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功能 |
Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.
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总结 |
The protein encoded by this gene interacts with signalingpathways to coordinately regulate cell growth, cell proliferation,apoptosis, autophagy, and cell migration. This tumor suppressoralso enhances retinoblastoma 1 gene expression in cancer cells.Alternative splicing results in multiple transcript variantsencoding distinct isoforms.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000
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别名 |
RB1-inducible coiled-coil protein 1, FAK family kinase-interacting protein of 200 kDa, FIP200, RB1CC1, KIAA0203, RBICC
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图像 |
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说明书 |
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数量 |
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