全部产品分类
品牌 |
Leading Biology | 货号 |
APG01921G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality APG8a/b(MAP1LC3A/B) antibody.
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分子量 |
14688 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes Localizes also to discrete punctae along the ciliary axoneme (By similarity).
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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免疫原 |
100-125 aa
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靶点 |
This Cleaved-APG8a/b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-125 amino acids from human Cleaved-APG8a/b.
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亚型 |
Rabbit Ig
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通用名 |
MAP1ALC3
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基因ID |
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UniProt ID |
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功能 |
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
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总结 |
The product of this gene is a subunit of neuronalmicrotubule-associated MAP1A and MAP1B proteins, which are involvedin microtubule assembly and important for neurogenesis. Studies onthe rat homolog implicate a role for this gene in autophagy, aprocess that involves the bulk degradation of cytoplasmiccomponent.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IF, WB, IHC-P, E
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稀释方法 |
IF~~1:100
WB~~1:1000
IHC-P~~1:50~100
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别名 |
Microtubule-associated proteins 1A/1B light chain 3B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B, Microtubule-associated protein 1 light chain 3 beta, MAP1LC3B, MAP1ALC3
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图像 |
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说明书 |
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数量 |
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