全部产品分类
品牌 |
Leading Biology | 货号 |
APR07037G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LRP1 antibody.
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分子量 |
504606 Da
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细胞定位 |
Antigen Cellular Localization:
Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
A synthetic peptide corresponding to residues in human LRP1 was used as an immunogen.
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克隆号 |
EPR3724
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通用名 |
A2MR, APR
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基因ID |
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UniProt ID |
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功能 |
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
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总结 |
The LDL receptor-related protein (LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in various biological processes including lipoprotein metabolism, degradation of proteases, activation of lysosomal enzymes, and cellular entry of bacterial toxins and viruses. LRP1 can recognize more than 30 distinct ligands, bind a large number of cytoplasmic adaptor proteins via determinants located on its cytoplasmic domain in a phosphorylation-specific manner, and can associate with and modulate the activity of other transmembrane receptors such as integrins and receptor tyrosine kinases (1). This multi-talented receptor has been implicated in regulation of platelet derived growth factor receptor activity, integrin maturation and recycling, and focal adhesion disassembly (2).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, IF
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稀释方法 |
WB~~1:20000~50000
IHC~~1:100~250
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别名 |
Prolow-density lipoprotein receptor-related protein 1, LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD91, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD, LRP1, A2MR, APR
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图像 |
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说明书 |
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数量 |
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