全部产品分类
品牌 |
Leading Biology | 货号 |
APR00505G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Urotensin II Receptor Antibody.
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分子量 |
42707 Da
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宿主 |
Rabbit
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种属反应性 |
Rat
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靶点 |
Peptide (C)RPLDTVQRSKGYRK, corresponding to amino acid residues 154-167 of rat UTIIR (Accession P49684).??2nd intracellular loop.
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基因ID |
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UniProt ID |
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总结 |
Urotensin II is a very powerful vasoconstrictive substance.The human Urotensin II receptor (UTIIR) was originally isolated as an orphan receptor (GPR14) in neural and sensory tissues.1,2 Urotensin II is expressed in various human tissues suchas CNS, skeletal muscle, smooth muscle, pancreas, and heart.3-5Binding of Urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that Urotensin II is also expressed in various kindsof tumor cells such as of adrenal tumors and neuroblastomas.In those cells Urotensin II was reported to stimulate cell growth.7-9Abgent is pleased to offer a highly specific antibody directed against the 2nd cytoplasmic loop of therat UTIIR. Anti-Urontenisn II Receptor antibody (#AG1284) can be used in Western blot anlaysis and immunohistochemical applications, and recognizes UTIIR in rat samples.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
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图像 |
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说明书 |
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数量 |
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