全部产品分类
品牌 |
Leading Biology | 货号 |
APR06710G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CCDC141 Antibody.
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分子量 |
166261 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm {ECO:0000250|UniProtKB:A2AST1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A2AST1}. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner. {ECO:0000250|UniProtKB:A2AST1}
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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靶点 |
CCDC141; At least four isoforms of CCDC141 are known to exist.
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亚型 |
IgG
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通用名 |
CAMDI {ECO:0000303|PubMed:20956536}
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基因ID |
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UniProt ID |
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功能 |
Plays a critical role in radial migration and centrosomal function.
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总结 |
CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IF, E
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图像 |
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说明书 |
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数量 |
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