全部产品分类
品牌 |
Leading Biology | 货号 |
APR06479G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality AIFM3 Antibody.
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分子量 |
66791 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
AIFM3;
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亚型 |
IgG
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通用名 |
AIFL
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基因ID |
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UniProt ID |
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功能 |
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
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总结 |
AIFM3 Antibody: Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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图像 |
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说明书 |
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数量 |
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