全部产品分类
品牌 |
Leading Biology | 货号 |
APR00495G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KV1.5 (extracellular) Antibody.
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分子量 |
66553 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Rat
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靶点 |
Peptide (C)DERELLRHPPVP(K), corresponding to amino acid residues 268-279 of rat Kv1.5 (Accession P19024). 1st extracellular loop.
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基因ID |
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UniProt ID |
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总结 |
KV1.5 is a mammalian voltage-dependent K+channel, homologous to theDrosophilaShakerK+channel. KV1.5 was first cloned from rat brain1. EightShakerrelated genes exist in mammals constituting the KV1, subfamily of the large KVchannel family of genes2.A functional KV1 channel is either a membrane spanning homotetramer or heterotetramer, which is composed of members of the same subfamily. In addition several auxiliary subunits and intracellular proteins might interact with the channel and affect its function.The structure of KV1.5 channel is similar to all KVchannels and includes six membrane spanning helixes creating a voltage sensor domain and a pore domain2.The channel is expressed in cardiac and smooth muscle tissue (colon, aorta, stomach andpulmonary artery) as well as in neurons and kidney2. A loss of function mutation in the gene encoding the channel was found in atrial fibrilation patients, stressing its role as a cardiac action potential regulator3.The functional channel is considered a transient (A-type) channel and shows prominent inactivation. Therefore, KV1.5 activity influences the membrane potential and excitability of neurons and muscle.KV1.5 channels are sensitive to high doses of TEA (330 mM) and low doses of 4-AP (0.27 mM), the “classical” non-selective potassium channel blockers2.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:200-1:2000
IHC~~1:200
FC~~1:20
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图像 |
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说明书 |
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数量 |
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