全部产品分类
品牌 |
Leading Biology | 货号 |
APR00908G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RNF169 antibody - N-terminal region.
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分子量 |
77kDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus, nucleoplasm. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
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通用名 |
KIAA1991
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基因ID |
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UniProt ID |
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功能 |
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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图像 |
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说明书 |
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数量 |
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