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> 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > Phospho-Ser459 Protein Tyrosine Phosphatase H1 Antibody品牌 |
Leading Biology | 货号 |
APR03402G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser459 Protein Tyrosine Phosphatase H1 Antibody.
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分子量 |
104 KDa
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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靶点 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser459 conjugated to KLH.
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基因ID |
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UniProt ID |
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总结 |
Protein-tyrosine Phosphatase H1 (PTPH1) has recently been identified as a specific p38γMAPK phosphatase which is mediated through PDZ interaction (Hou et al., 2010). Ras has beendemonstrated to increase both p38γand PTPH1 protein expression, and there is a coupling of increasedp38γand PTPH1 protein expression in primary colon cancer tissues (Hou et al., 2010). Phosphorylation ofPTPH1 at Ser459 leads to PTPH1 stabilization, which plays an important role in Ras oncogenesis and stressresponse (Hou et al., 2012). Additionally, phosphorylation of PTPH1 Ser459 reveals a novel mechanism bywhich MAPK signals through PTPH1 to regulate cellular response (Hou et al., 2012).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~ 1:1000
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图像 |
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说明书 |
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数量 |
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