全部产品分类
品牌 |
Leading Biology | 货号 |
APR03179G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RANBP2 / TRP1 Antibody (aa1050-1100).
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分子量 |
358kDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat, Bovine
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靶点 |
Region between residue 1050 and 1100 of human RAN binding protein 2 using the numbering given in entry NP_006258.3 (GeneID 5903).
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通用名 |
NUP358
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基因ID |
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UniProt ID |
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功能 |
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB.
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总结 |
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, IP
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稀释方法 |
IHC-P (1:100), IP (2-5 μg/mg lysate), WB (1:2000-1:10000)
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图像 |
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说明书 |
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数量 |
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| 5 | Leading Biology | APR11512G | Bestrophin-1 (extracellular) Antibody | 50 μl | Polyclonal Antibodies |
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