全部产品分类
品牌 |
Leading Biology | 货号 |
APG01231G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RAD17 Antibody (aa325-375).
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分子量 |
77kDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage
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宿主 |
Goat
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种属反应性 |
Human
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靶点 |
Region between residues 325 and 375 of human Rad17 using the numbering given in entry NP_002864.1 (GeneID 5884).
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通用名 |
R24L
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基因ID |
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UniProt ID |
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功能 |
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
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总结 |
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, PLA
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稀释方法 |
IHC-P (5 μg/ml), PLA (1:1000-1:10000), WB (1:2500-1:15000)
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图像 |
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说明书 |
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数量 |
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