全部产品分类
品牌 |
Leading Biology | 货号 |
APG01204G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PDCD4 Antibody (aa210-221).
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分子量 |
52kDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum
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宿主 |
Goat
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种属反应性 |
Human, Mouse, Rat, Rabbit, Hamster, Monkey, Chicken, Goat, Horse, Xenopus, Bovine, Guinea Pig, Dog
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靶点 |
Human PDCD4. This antibody is expected to recognize all reported isoforms (NP_055271.2; NP_663314.1; NP_001186421.1).
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通用名 |
H731
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基因ID |
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UniProt ID |
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功能 |
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
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总结 |
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E
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稀释方法 |
ELISA (1:128000), IHC-P (5 μg/ml), WB (0.1-0.3 μg/ml)
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图像 |
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说明书 |
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数量 |
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