全部产品分类
品牌 |
Leading Biology | 货号 |
APG01121G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality A2M / Alpha-2-Macroglobulin Antibody.
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分子量 |
163kDa
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细胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Goat
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种属反应性 |
Human
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靶点 |
Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-goat serum as well as purified and partially purified a2-Macroglobulin human plasma.
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通用名 |
CPAMD5
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基因ID |
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UniProt ID |
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功能 |
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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总结 |
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E, IP
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稀释方法 |
ELISA (1:40000-1:200000), IHC-P (3.75 μg/ml),
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图像 |
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说明书 |
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数量 |
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