全部产品分类
品牌 |
Leading Biology | 货号 |
APR02250G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NLRP2 / NALP2 Antibody (C-Terminus).
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分子量 |
121kDa
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2
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通用名 |
NALP2, NBS1, PAN1, PYPAF2
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基因ID |
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UniProt ID |
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功能 |
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
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总结 |
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P
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稀释方法 |
IHC-P (5 μg/ml), WB (1-2 μg/ml),
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图像 |
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说明书 |
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数量 |
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