全部产品分类
品牌 |
Leading Biology | 货号 |
APR06963G |
产品分类 |
Polyclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UBA6 Antibody (C-term).
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分子量 |
H=118,66;M=118 KDa
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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免疫原 |
861-889 aa
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靶点 |
This UBA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-889 amino acids from the C-terminal region of human UBA6.
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通用名 |
MOP4, UBE1L2
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基因ID |
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UniProt ID |
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功能 |
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
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总结 |
Modification of proteins with ubiquitin (UBB; MIM 191339)or ubiquitin-like proteins controls many signaling networks andrequires a ubiquitin-activating enzyme (E1), a ubiquitinconjugating enzyme (E2), and a ubiquitin protein ligase (E3).UBE1L2 is an E1 enzyme that initiates the activation andconjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed17597759]).
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~0.25
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图像 |
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说明书 |
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数量 |
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